Hypothalamic-pituitary-adrenal activity in aged, cognitively impaired and cognitively unimpaired rats

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Hypothalamic-pituitary-adrenal activity in aged, cognitively impaired and cognitively unimpaired rats.

There is a tendency for increased hypothalamic-pituitary-adrenal (HPA) activity with age in the rat, and the resulting elevations in circulating glucocorticoid levels have been implicated in the occurrence of hippocampal pathology and memory deficits. In the experiments reported here, we examined whether HPA dysfunction is selectively associated with cognitive impairments in a population of age...

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ژورنال

عنوان ژورنال: The Journal of Neuroscience

سال: 1990

ISSN: 0270-6474,1529-2401

DOI: 10.1523/jneurosci.10-10-03247.1990